Effects of metabolic syndrome on infarct-related artery patency after thrombolysis for acute myocardial infarction
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Metabolic syndrome is associated with poorer in-hospital outcome and survival following myocardial infarction. The study was designed to investigate the impact of metabolic syndrome on infarct-related artery patency in patients treated with thrombolytic therapy following acute myocardial infarction. To this end, 116 patients with acute ST elevation myocardial infarction receiving thrombolytic therapy within 12 h of chest pain onset were analysed retrospectively. Thrombolysis in myocardial infarction (TIMI) flow grade and corrected TIMI frame count were used to analyse blood flow in the infarct-related artery. Metabolic syndrome defined by NCEP ATP III criteria was present in 55.2% of the patients. In patients with metabolic syndrome, the proportion of those achieving TIMI grade 3 flow after thrombolysis was significantly lower, and corrected TIMI frame counts were significantly higher than in those without metabolic syndrome. Multivariate logistic regression analysis revealed metabolic syndrome to be the only independent predictor of TIMI flow less than 3. Thus, patients with metabolic syndrome exhibit lower rates of TIMI grade 3 flow and higher corrected TIMI frame counts after thrombolytic therapy following acute myocardial infarction.
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