Metabolic syndrome increases the risk of incident type 2 diabetes, independently of impaired fasting glucose
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Current concept about the metabolic syndrome is that it predicts both incident diabetes as well as cardiovascular disease. A total of 1935 nondiabetic adult Japanese subjects were followed up prospectively in order to investigate whether metabolic syndrome predicted incident type 2 diabetes more effectively than impaired fasting glucose (IFG). During a mean follow-up period of 11.8 years, 286 subjects developed type 2 diabetes. After adjusting for confounding factors, the multivariate-adjusted hazard ratio (HR) for incident type 2 diabetes was significantly higher in patients with metabolic syndrome of both genders as compared to those without metabolic syndrome. The multivariate-adjusted HR of metabolic syndrome for type 2 diabetes was slightly lower in men and similar in women when compared to that of IFG, rising progressively as the number of individual metabolic syndrome components increased, irrespective of IFG. Moreover, the multivariate-adjusted risk of type 2 diabetes was significantly higher in subjects with metabolic syndrome alone or IFG alone than in those with neither metabolic syndrome nor IFG, markedly increasing in subjects presenting both conditions. These findings suggest that metabolic syndrome significantly increases the risk of type 2 diabetes, independent of IFG, and that screening for metabolic syndrome is an easy means to identify subjects at risk for type 2 diabetes.
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