Lower high-density lipoprotein cholesterol levels correlate with adverse prognosis in patients with advanced heart failure
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To evaluate the prognostic value of high-density lipoprotein cholesterol (HDL-C) levels in advanced heart failure (HF), 132 consecutive patients listed for heart transplantation were stratified by underlying aetiology (ischaemic vs non-ischaemic) and followed up for the primary composite end-points of HF hospitalisation or death. Survival analysis using Cox proportional hazard model revealed that reduced HDL-C (<33 mg/dL) was the most significant predictor of HF hospitalisation or death, irrespective of HF aetiology, whereas low cholesterol and low-density lipoprotein cholesterol alone were not shown to be independent outcome predictors. Thus, low HDL-C levels predict clinical worsening or death in advanced HF patients. Further research will determine whether low HDL-C is an emerging marker or a modifiable risk factor for this condition.
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