Metabolic syndrome in early pregnancy associated with higher risk for preterm birth
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The analysis aimed to determine the association between metabolic syndrome in early pregnancy and the risk of preterm birth in the mother-child cohort study conducted in Crete in 2007-2009. Multivariable log-binomial regression model analysis revealed that women with metabolic syndrome were at high risk for preterm birth, the highest risk being observed for medically-indicated preterm births. Among the individual components of the metabolic syndrome, hypertension was the most significant risk factor, with a 10 mmHg elevation in diastolic blood pressure increasing relative risk for preterm birth by 29%. A per-unit increase in the low-density lipoprotein/high-density lipoprotein cholesterol ratio increased the risk by 19%. Furthermore, foetal weight growth restriction was associated with elevated levels of maternal insulinaemia and diastolic blood pressure in early pregnancy. These results suggest that women with metabolic syndrome in early pregnancy present a higher risk for preterm birth.
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