Postprandial measurements of triglyceride-rich lipoproteins do not predict the presence of coronary artery disease in diabetes mellitus
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Subjects with type 2 diabetes have been shown to exhibit elevated fasting and postprandial (PP) plasma triglycerides (TG). This case-control study on 84 diabetic patients with coronary artery disease (CAD) and 80 diabetic patients without CAD was designed to evaluate the hypothesis that diabetic patients with or without CAD would present similar PPTG levels, whilst CAD+ subjects would have elevated number of small (d<1.006 g/L) lipoprotein particles. Several markers of PP lipid metabolism were measured over 10 h following a fat load. No significant difference in any measure of PP lipid metabolism was found between CAD+ and CAD- subjects, except for apoB48 (the chylomicron hallmark lipoprotein), which was higher in CAD- patients. A total of 69 CAD- participants were followed up for a mean duration of 8.7 years; of these, 33 remained free of any cardiovascular event. At baseline, there was no significant difference in any measure of PP lipid metabolism between those 33 who remained CAD- and either the 36 original CAD- who subsequently developed CAD or the original CAD+ group. Thus, PP measurements of TG-rich lipoproteins do not predict the presence of CAD in subjects with diabetes mellitus.
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