Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are associated with atherogenic changes in serum lipid and hsCRP levels
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The two prediabetic states (impaired fasting glucose (IFG) and impaired glucose tolerance (IGT)) both predict increased risk for type 2 diabetes as well as macroangiopathy. The two conditions, while often overlapping, may confer distinct cardiovascular risk. The study was designed to evaluate components of cardiovascular risk related to serum lipid and hsCRP levels in 445 subjects with prediabetes (IFG and IGT), 318 patients with newly-diagnosed diabetes (NDD), and 477 age- and BMI-matched control subjects with normal glucose tolerance (NGT). When compared to NGT, both IFG and IGT exhibited significant differences in atherogenicity of serum lipids and in hsCRP levels. Compared to IFG, subjects with IGT presented significantly higher triglycerides and free fatty acids and significantly lower HDL cholesterol. Compared to NDD, subjects with IFG showed significantly higher levels of HDL cholesterol and lower levels of triglycerides and hsCRP. Lastly, subjects with IGT differed from NDD only by their lower hsCRP. In conclusion, although both categories of prediabetes, IFG and IGT, are associated with increased cardiovascular risk, IGT is characterized by a more atherogenic risk profile, closer to that seen in NDD.
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