Prehypertension associated with insulin resistance
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Prehypertension, defined as systolic blood pressure (BP) in the range of 120-139 mmHg or diastolic blood pressure in the range of 80-89 mmHg, is a strong predictor of the development of hypertension. This cross-sectional study including 83 prehypertensive and 192 normotensive subjects aimed to investigate whether prehypertension was associated with insulin resistance (IR). All subjects were given a 75-g oral glucose tolerance test (OGTT), indices of which were used to estimate insulin sensitivity. Compared to normotensive subjects, prehypertensive subjects were more insulin-resistant. Although no difference was seen between the two groups in insulin response during OGTT, the prehypertension group maintained significantly between-group differences in glucose response, even when incremental insulin levels were added to covariates for adjustments. In conclusion, prehypertension appears to be associated with insulin resistance. This data suggests that prehypertensive patients cannot handle an oral glucose challenge as adequately as normotensive subjects, which may be accounted for by insulin resistance associated with the prehypertensive stage.
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