Metabolic syndrome impacts on the increase in high sensitivity C-reactive protein levels in patients with acute coronary syndrome
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High sensitivity C-reactive protein (hs-CRP) is a reliable marker of systemic inflammation as well as a modifiable predictor of cardiovascular disease risk. It is still unclear whether metabolic syndrome may cause a predisposition for elevated hs-CRP response in patients with acute coronary syndrome (ACS). The study was designed to investigate the interaction between hs-CRP levels and metabolic syndrome in 273 consecutive patients with a first ACS and 261 metabolic syndrome (MetS) patients without ACS. Study participants were divided in three groups: 1) MetS+ ACS-, 2) MetS- ACS+, and 3) MetS+ ACS+. Hs-CRP levels were lowest in MetS+ ACS- patients and highest in MetS+ ACS+. Significant predictors for elevated hs-CRP were the presence of ACS, presence of metabolic syndrome, troponin elevation and body mass index. In conclusion, the presence of metabolic syndrome appears to have an impact on the increase in hs-CRP observed with an ACS event. These findings suggest that a heightened baseline inflammatory status associated with the metabolic syndrome phenotype may predispose ACS patients to an elevated hs-CRP response.
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