Overweight in midlife increases later risk of dementia
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This study using data collected in the Swedish Twin Registry of 1152 participants, 45-65 years of age, was designed to examine whether overweight in midlife increases risk of dementia in later life. After adjusting for confounding variables, logistic regression analyses revealed that midlife overweight (defined by body mass index measurement in 1963) was associated with a significant increase in risk of dementia, Alzheimer’s disease, but not vascular dementia. These associations remained unchanged after further adjusting for diabetes and vascular diseases. There was no significant interaction between overweight and APOE epsilon-4 polymorphism, which indicates that having both risk factors does not multiply dementia risk. These study results further support the concept that midlife overweight increases the risk of both Alzheimer’s disease and vascular dementia for men and women.
Abstract
