Metabolic syndrome associated with chronic kidney disease in a large Korean cohort
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This retrospective study examined the association between metabolic syndrome and risk for developing chronic kidney disease (CKD) in 60,921 healthy Korean adults recruited from two health promotion centres. The abbreviated equation developed by the Modification of Diet in Renal Disease (MDRD) was used to estimate glomerular filtration rate (eGFR), CKD being defined as an eGFR<60 mL/min/1.73 m2 and/or the presence of proteinuria. Prevalence of CKD was 7.2%. Compared with subjects without metabolic syndrome, those with metabolic syndrome had a significantly higher prevalence of CKD. Furthermore, the prevalence of CKD increased and eGFR decreased as the number of metabolic syndrome components increased. Multiple linear analyses revealed that each individual metabolic syndrome component was negatively associated with eGFR. Compared with subjects without metabolic syndrome, those with metabolic syndrome had a multivariate-adjusted odds ratio of 1.68 for CKD. In conclusion, metabolic syndrome was associated with CKD in this large Korean cohort.
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