Abdominal obesity underlies a high risk of all-cause and CV mortality in patients with end-stage renal failure
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The aim of this prospective cohort study was to investigate the predictive value of anthropometric measurements of abdominal obesity for all-cause and cardiovascular (CV) death in 537 patients with end-stage renal disease (ESRD). BMI-adjusted Cox models revealed that waist circumference was a direct predictor of all-cause and CV mortality, whereas BMI showed an inverse relationship with these outcomes. The incidence rates of overall and CV death were maximal in patients with relatively lower BMI scores and higher waist circumferences, and minimal in those with higher BMI scores and lower waist circumferences, suggestive of diverging fat as well as lean body mass. After adjusting for CV comorbidities and traditional and emerging risk factors, the predictive power of waist circumference for all-cause and CV mortality remained significant. Waist-to-hip ratio was also found to be significantly related to all-cause and CV mortality. Thus, abdominal obesity underlies a high risk of all-cause and CV mortality in ESRD patients.
Abstract
