Cigarette smoking positively associated with incident impaired fasting glucose
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Given the current emphasis on the role of excess fat in driving the type 2 diabetes epidemics, it is often debated whether tobacco smoking increases type 2 diabetes risk, as current smokers are usually leaner, and smoking cessation is associated with weight gain. The study was designed to determine whether cigarette smoking was associated with increased odds of converting from normoglycaemia to impaired fasting glucose (IFG) in 1455 participants from the Western New York Health Study who were free of type 2 diabetes and cardiovascular disease at baseline. Among 924 normoglycaemic participants at baseline, 101 converted to IFG over 6 years. At baseline, IFG converters were older, had a higher body mass index, and were more likely to be hypertensive, current tobacco smokers and to have a family history of type 2 diabetes. Multivariate logistic regression revealed that the odds ratio of incident IFG among former smokers was 1.68, and 2.35 among current smokers, compared with subjects who remained normoglycaemic. In conclusion, after accounting for several putative risk factors, smoking appears to be positively associated with incident IFG.
Abstract
