Serum high-density lipoprotein cholesterol as independent predictor of one-year mortality after percutaneous coronary interventions
Document Actions
The study aimed to determine whether low level of high-density lipoprotein cholesterol (HDL-C), a marker for cardiovascular risk and coronary artery disease progression, is also a useful prognostic indicator after percutaneous coronary intervention (PCI). One-year mortality and repeat revascularization were evaluated in relation to baseline HDL-C in a cohort of 4088 patients undergoing PCI, patients being classified into HDL-C quartiles. One-year mortality and coronary revascularization were significantly higher in the lowest quartile HDL-C group (<35 mg/dL), as compared to the other groups. In men with a HDL-C <33 mg/dL and in women with a HDL-C <38 mg/dL, 1-year mortality was significantly higher. Multivariable analysis revealed that a very-low HDL-C was associated with nearly twofold the risk of death after adjusting for other independent outcome predictors. In conclusion, a baseline HDL-C <35 mg/dL appears to be an important prognostic indicator in patients with coronary artery disease undergoing PCI. Baseline HDL-C levels <33 mg/dL for men and <38 mg/dL for women are associated with higher 1-year mortality after PCI.
Abstract
