Low HDL-C and high TC/HDL-C increase CVD mortality in either diabetic or nondiabetic subjects

Data from 14 European population-based prospective studies including 9132 men and 8631 women were jointly analyzed in order to evaluate the impact of dyslipidaemia on cardiovascular disease (CVD) mortality in relation to fasting and post-load (2-h) plasma glucose levels in subjects without prior history of diabetes. During the 10-year follow-up, 871 CVD deaths occurred. For HDL-C, multivariate-adjusted hazard ratios (HRs) for CVD mortality were 0.84 for normoglycaemia, 0.66 for isolated fasting hyperglycaemia, 1.03 for isolated post-load hyperglycaemia and 0.67 for combined (fasting and post-load) hyperglycaemia (CH). For total cholesterol (TC) to HDL-C ratio, HRs were 1.14, 1.44, 0.94 and 1.26, respectively. For TC and triglycerides (TG), HRs were not significant for most of the glucose categories excepting TG in subjects with CH. In conclusion, low HDL-C and high TC/HDL-C increase CVD mortality in either diabetic or nondiabetic subjects as defined by fasting glucose criteria but not the 2-h criteria. TG was a significant CVD risk predictor only in the presence of combined hyperglycaemia or diabetes.

Abstract

Keywords:
Cardiovascular risk – Cholesterol – Dyslipidaemia – HDL-C – IFG – IGT – Plasma glucose – Triglycerides