Adiponectin as a biomarker of the relationship between adiposity and bone mineral status
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Some of the protective effects of fat on bone mineral density (BMD) may be mediated by altered levels of adipocytokines. Although changes in adiponectin levels, an insulin-sensitizing adipocytokine, have been associated with insulin resistance and osteoporosis, the mechanism of this relationship is still unclear. This cross-sectional, observational study including 84 postmenopausal women referred for osteoporosis screening was designed to determine whether insulin resistance (HOMA-IR index), and serum levels of the two adipocytokines adiponectin and leptin were associated with BMD. Multivariate analysis revealed an inverse relation between serum adiponectin level and femoral neck and lumbar BMD measurements. For total hip and forearm regions, no independent association between adipocytokines and BMD measurements was found. Contrarily, waist circumference was independently associated with BMD measurements. Adiponectin may represent a biomarker of the link between visceral fat mass and BMD in postmenopausal women. This association, however, is likely to be accounted for by specific body fat distribution proxis, such as waist circumference.
Abstract
