Prospective association between metabolic syndrome by NCEP ATP III and IDF definitions and incident diabetes
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The presence of a metabolic syndrome in nondiabetics predicts both cardiovascular and incident diabetes risks. The prospective association between metabolic syndrome defined by both NCEP ATP III and IDF criteria and incident diabetes was investigated in 2796 adult men and women participating in the European Prospective Investigation into Cancer and Nutrition-Potsdam Study. The follow-up period was 6.9 years and incident diabetes was identified by self-reporting and confirmed from patient’s attending physician. When using the NCEP ATP III and IDF definitions, the adjusted hazard ratios were 4.62 and 4.59, respectively, and those for the NCEP ATP III but not the IDF definition were higher in women than in men. When contrasted with participants who fulfilled no metabolic syndrome criterion, the adjusted hazard ratio for having three or more abnormalities when using the NCEP ATP III definition increased to 22.50. Among the metabolic syndrome discrete components, abdominal obesity and, not surprisingly, hyperglycaemia were most strongly associated with incident diabetes. In conclusion, both definitions of the metabolic syndrome provided similar estimates of relative risk for incident diabetes.
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