Both diabetes and metabolic syndrome appear to be independently associated with higher osteoporosis prevalence
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The protective effect of obesity on bone mineral density (BMD) may be blurred in patients with metabolic syndrome and/or diabetes. The aim of this cross-sectional study was to investigate whether subjects with metabolic syndrome alone show early signs of decreased BMD and osteoporosis, similar to those encountered in diabetic patients. To this end, BMD was measured in 3458 men without diabetes and in 735 with type 2 diabetes. In addition, BMD changes in men without diabetes and metabolic syndrome were compared to those observed in men without diabetes but with metabolic syndrome (ATP III). Hip BMD was significantly lower and incidence of osteoporosis was significantly higher in patients with diabetes as compared to age- and body mass index (BMI)-matched patients without diabetes. Spine BMD was significantly higher in patients with diabetes as compared to those without diabetes but similar when subjects were matched for BMI. Hip BMD was significantly lower and incidence of osteoporosis was significantly higher in patients with metabolic syndrome as compared to those without metabolic syndrome. In conclusion, hip BMD is lower in patients with diabetes than in those without diabetes, and its value is similar in diabetic and nondiabetic patients with metabolic syndrome. Both diabetes and metabolic syndrome appear, therefore, independently associated with higher osteoporosis and lower hip BMD.
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