Independent association between elevated concentrations of adiponectin and inducible ischaemia in stable coronary heart disease
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It is still uncertain whether raised levels of adiponectin, an insulin-sensitizing adipose tissue-derived adipokine whose secretion translates into favourable cardiovascular profile, is associated with an increased risk of coronary heart disease (CHD). This cross-sectional study of 899 outpatients with documented CHD aimed to determine whether higher adiponectin levels were associated with exercise-induced ischaemia by means of stress echocardiography. Among patients, 217 exhibited stress-induced ischaemia. Elevated adiponectin levels were associated with a greater risk of harbouring inducible ischaemia, with each standard deviation increase in log adiponectin being associated with a 35% greater odds of inducible ischaemia. After adjusting for traditional cardiovascular risk factors and other measures of cardiac function, this association remained present, though attenuated. In conclusion, elevated adiponectin levels appear to be independently associated with inducible ischaemia in stable CHD patients. These findings raise the possibility that the presence of chronic inducible ischaemia might alter the cardioprotective effects seemingly associated with adiponectinaemia in lean, healthy subjects.
Abstract
