Identification of type 2 diabetic patients at increased risk of chronic kidney disease by ATP III but not IDF criteria
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Central adiposity is a major component of the metabolic syndrome phenotype. Previous studies showed an association between obesity, proteinuria, and chronic kidney disease (CKD). This study aimed to examine the association between CKD and metabolic syndrome using both the National Cholesterol Education Program’s Adult Treatment Panel III (NCEP ATP III) and the International Diabetes Federation (IDF) definitions in 6350 Chinese subjects presenting with type 2 diabetes. Multivariate logistic regression analysis of the association between CKD and metabolic syndrome defined by either definition revealed that the presence of metabolic syndrome was not associated with CKD when using the IDF definition whilst being significantly associated with CKD when using the ATP III criteria. Regarding individual components of the metabolic syndrome, raised triglyceride and hypertension were statistically associated with CKD. In conclusion, in type 2 diabetes, the ATP III but not the IDF definition identifies a subgroup of patients at high risk of CKD.
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