Inverse graded relation between 14-year increase in HDL cholesterol and subsequent coronary heart disease in otherwise healthy males
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This prospective study was designed to investigate the association between changes in high-density lipoprotein cholesterol (HDL-C) and risk of subsequent coronary heart disease (CHD) using Cox proportional hazards modelling. To this end, data from 4501 male physicians participating in the Physician’s Health Study I, with HDL-C measured in 1982 and again 14 years thereafter was used. Subjects were divided into categories of those with a decrease, no change, a small increase, and a large increase in HDL-C. Compared to subjects presenting with a decrease in HDL-C, multivariable-adjusted hazard ratios for CHD were 0.66 for subjects with no change, 0.56 for those with a HDL-C increase of 2.5 to 12.5 mg/dL, and 0.43 for subjects with a HDL-C increase ≥12.5 mg/dL. These findings are consistent with an inverse graded relation between 14-year increase in HDL-C and risk of subsequent CHD in otherwise healthy males, and lend support to HDL-C as potential therapeutic target for primary CHD prevention.
Abstract
