Mild increase in body mass index shown to be associated with prehypertension in a general Japanese population
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Subjects with prehypertension (pre-HT) have been shown to have an increased risk of cardiovascular disease (CVD). This study enrolling 4706 males and 7342 females aimed to assess the prevalence and determinants of pre-HT in a general Japanese population. Pre-HT was defined as systolic blood pressure (SBP) 120-139 mmHg and/or diastolic blood pressure (DBP) 80-89 mmHg according to the Seventh Report of the Joint National Committee. The prevalence of pre-HT was 34.8% among males and 31.8% among females. Body mass index (BMI) >23.0 kg/m2 was the strongest determinant of pre-HT whereas the other determinants of pre-HT were hyperlipidaemia and aging. In females, determinants of pre-HT were impaired glucose tolerance, diabetes and a family history of HT in both parents, whereas in males, the only predictor was alcohol drinking. Even a mild increase in BMI (23.0-24.9 kg/m2) was associated with increased risk of pre-HT. The BMI threshold associated with pre-HT appeared to be lower in the general Japanese population as compared to those of Western countries.
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