Insulin as the only reliable biomarker to differentiate metabolic syndrome status in an obese population with elevated waist circumference
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This cross-sectional study was aimed to assess which specific adipose tissue factors would discriminate the presence of a metabolic syndrome in a strictly obese population meeting waist circumference (WC) criteria for the metabolic syndrome. Biomarkers measured included high sensitivity C-reactive protein (hs-CRP), leptin, adiponectin, and total insulin. Among the 148 obese subjects studied, 33.8% met metabolic syndrome criteria and insulin was the only biomarker to consistently differentiate between presence and absence of metabolic syndrome. With the exception of leptin, all biomarkers had a statistically significant relationship with increasing criteria scoring for the metabolic syndrome. In conclusion, insulin was the only reliable biomarker to differentiate metabolic syndrome status in this strictly obese population with elevated waist circumference. Based on these findings, the authors suggest that differences in hs-CRP, leptin, and adiponectin are a reflection of their measurement in subjects with statistically different amounts of adipose tissue.
Abstract
