Waist circumference prospectively linked to colon cancer risk
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Insulin resistance and hyperinsulinaemia are established risk factors for colorectal cancer. This study was aimed to investigate the association between waist circumference and incident colorectal cancer, using data from 95,151 participants of the Cancer Prevention Study-II Nutrition Cohort, and taking confounders into account (height, education, smoking, alcohol intake, physical activity, vitamin, nonsteroidal anti-inflammatory drugs use, history of colorectal endoscopy, postmenopausal hormone replacement, race/ethnicity, family history of colorectal cancer, history of colon polyps, diabetes, and red/processed meat, calcium, vegetable and energy intakes). Between 1997 and 2005, a total of 953 incident colorectal cancer cases occurred. For both genders, waist circumference was associated with increased colorectal cancer incidence, as was elevated body mass index (BMI), a measure of general adiposity. After adjusting for BMI, waist circumference remained associated with a nonstatistically significant increase in colorectal cancer incidence. In conclusion, waist circumference is associated with increased colorectal cancer risk, which appears to be partially independent of BMI.
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