High-molecular weight adiponectin as a better marker of the extent of coronary atherosclerosis than total adiponectin
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Low circulating adiponectin has been linked to atherosclerosis. There is considerable evidence that the high-molecular weight (HMW) complex of adiponectin is the major active form of this adipokine rather than total adiponectinaemia (summative of low-molecular weight adiponectin trimers, medium-molecular weight adiponectin hexamers and HMW adiponectin oligomers). In order to investigate whether HMW adiponectin was associated with the extent of coronary artery disease (CAD), associations among CAD, HMW adiponectin and the HMW/total-adiponectin ratio were assessed in 240 male patients undergoing elective coronary angiography. Significant inverse correlations between angiographic scores, HMW adiponectin and the HMW/total-adiponectin ratio were found (P<0.001). In multivariable regression analyses, HMW adiponectin and the HMW/total-adiponectin ratio were significantly associated with the extent of CAD (both P<0.001). The predictive value of HMW adiponectin and the HMW/total-adiponectin ratio as biomarker of coronary atherosclerosis extent exceeded that of total adiponectin. Based on these results, the authors conclude that HMW adiponectin appears to be a better marker for angiographically assessed CAD extent than total adiponectin in male patients.
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