Circulating adiponectin levels shown to be a useful predictor of coronary endothelial function
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This study was aimed to assess whether circulating adiponectin levels are a good predictor of coronary endothelial function. To this end, coronary endothelial function was evaluated by coronary vascular response to acetylcholine (Ach) in 36 consecutive non-diabetic patients with normal to mildly diseased coronary arteries, and the relationship between coronary vasoreactivity and adiponectin or other parameters was investigated. Using simple-regression analysis, log-transformed adiponectin levels positively correlated with the percent change in coronary blood flow (CBF) and coronary artery diameter (CAD) induced by Ach (P<0.0001 for both) as did insulin resistance index (HOMA-R), body mass index (BMI), immunoreactive insulin, and triglyceride concentrations. Using multiple regression analysis, however, log-transformed adiponectin was the only independent predictor of the percent change of CBF and CAD (P<0.0001 for both). Based on these results, adiponectin appears to be a better predictor of coronary endothelial function than HOMA-R, BMI, immunoreactive insulin, and triglycerides. Since the relationship between adiponectin and coronary endothelial dysfunction was independent, adiponectinaemia may represent a novel noninvasive surrogate measurement of coronary endothelial dysfunction.
Abstract
