Insulin resistance linked to the components of the metabolic syndrome in Black and White youth, and to biomarkers of endothelial function in White youth

To assess the relationship of in vivo insulin sensitivity (IS) to the components of the metabolic syndrome and to endothelial dysfunction (ED) in youth, 216 subjects aged 8 to 19 years underwent a 3-h hyperinsulinaemic-euglycaemic clamp. Prevalences of central obesity, high triglycerides, low HDL, high blood pressure (BP), impaired fasting glucose and impaired glucose tolerance increased (P for trend for all <0.05) with decreasing IS in both Blacks and Whites. In Whites but not in Blacks, insulin resistance was associated (P<0.05) with increased circulating endothelial biomarkers ICAM-1 and E-selectin, whose elevations represent surrogate markers of ED, though these relationships did not remain significant after controlling for visceral adipose tissue.

Abstract

Keywords:
Abdominal adiposity - Endothelial dysfunction - HDL - High blood pressure - IFG - IGT - Insulin resistance - Metabolic syndrome - Obesity - Triglycerides - Visceral adipose tissue