Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease
Document Actions
Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease.
In this review, the authors discuss the discovery, origin, properties and regulation of the plasminogen activator inhibitor 1 (PAI-1), one of the primary regulators of the fibrinolytic system, and speculate about its potential role in vascular disease, fibrosis, obesity and the metabolic syndrome, and cancer.
Authors: Thromb Haemost 2005;93:631-40.
PMID/ref: Dellas C, Loskutoff DJ.
